Outlook The GLP-1 agonists are an impressive new option for weight loss, especially in the setting of type 2 diabetes due to their glucose-lowering benefits
Oral obesity pipeline targets focusing on GLP-1/GIP dual agonists (Ecnoglutide, CT-388, DAPIGLP-1 ), amylin analogs (Pramlintide, Cagrilintide, Petrelintide) and CB1 inverse agonists (Inv-101, JD-5037, MRI-1867) provide alternative mechanisms and possible complementary actions
Trials predominantly enrolled adults between roughly 30 and 75 with established type 2 diabetes or obesity, which the post calls the primary indication population with the strongest safety profile in trials
A phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors
however, changing to an alternative GLP-1 or GIP with a different excipient profile should be considered if hypersensitivity is unmanageable for the patient